Long-term progression in chronic manganism : Ten years of follow-up
Identifieur interne : 003A31 ( Main/Exploration ); précédent : 003A30; suivant : 003A32Long-term progression in chronic manganism : Ten years of follow-up
Auteurs : C.-C. Huang [Taïwan] ; N.-S. Chu [Taïwan] ; C.-S. Lu [Taïwan] ; R.-S. Chen [Taïwan] ; D. B. Calne [Canada]Source :
- Neurology [ 0028-3878 ] ; 1998.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
We studied the long-term clinical course of five patients with chronic manganese intoxication. The mean scores of the King's College Hospital Rating Scale for Parkinson's disease increased from 15.0 ± 4.2 in 1987 to 28.3 ± 6.70 in 1991 and then to 38.1 ± 12.9 in 1995. The deterioration was most prominent in gait, rigidity, speed of foot tapping, and writing. Tissue concentrations of manganese in blood, urine, scalp hair, and pubic hair returned to normal. Follow-up MRIs did not show paramagnetic high-signal intensity on T1-weighted images. The data indicate that clinical progression in patients with manganese parkinsonism continues even 10 years after cessation of exposure.
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Case study</term>
<term>Chronic</term>
<term>Complication</term>
<term>Evolution</term>
<term>Long term</term>
<term>Manganese</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Parkinsonism</term>
<term>Poisoning</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Intoxication</term>
<term>Manganèse</term>
<term>Chronique</term>
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<term>Complication</term>
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<front><div type="abstract" xml:lang="en">We studied the long-term clinical course of five patients with chronic manganese intoxication. The mean scores of the King's College Hospital Rating Scale for Parkinson's disease increased from 15.0 ± 4.2 in 1987 to 28.3 ± 6.70 in 1991 and then to 38.1 ± 12.9 in 1995. The deterioration was most prominent in gait, rigidity, speed of foot tapping, and writing. Tissue concentrations of manganese in blood, urine, scalp hair, and pubic hair returned to normal. Follow-up MRIs did not show paramagnetic high-signal intensity on T1-weighted images. The data indicate that clinical progression in patients with manganese parkinsonism continues even 10 years after cessation of exposure.</div>
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